114 / 144 danmap 2015 114 resistance in human clinical bacteria 8. textbox 8.2 carbapenemase producing bacteria in denmark, 2015 background: carbapenems comprise one of the only classes of antimicrobial agents that can be used for treatment of infec- tions with multi-resistant gram-negatives like klebsiella pneumoniae , escherichia coli , pseudomonas aeruginosa and acineto- bacter baumannii . treatment options for infections with carbapenem resistant bacteria are often none or suboptimal. resistance can be caused by the presence of various carbapenemases of which the most frequently occurring are k. pneumoniae car- bapenemase (kpc), oxacillinase (oxa), verona integron-encoded metallo-ß-lactamase (vim), and new delhi metallo- ? -lactamase (ndm), and imipenemase (imp). in recent years, danish departments of clinical microbiology (dcm) have on a voluntary basis submitted carbapenem resistant
