isolates-coli-carbapenemase-112.html
DANMAP 2015 3D
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danmap
2015
8. resistance in human clinical bacteria among the 135 isolates
belonging to st131, ctx-m-15 (56 %) was most common, followed by ctx-m-27 (20%), ctx-m-101 (11%) and ctx-m-14 (7%). the two isolates producing oxa-181 and cmy-2 belonged to st410, whereas the isolates producing oxa-48 belonged to st38. conclusion: from 2014 to 2015, the reported cases of 3gc-r ec slightly increased from 245 to 281 (261 and 294 including hyper ampc producers). comparing the distribution of esbls (including pampcs), carbapenemases and mlsts, from the present study to the results reported in danmap 2014, no remarkable changes were observed. as in previous danish studies of esbl- producing e. coli from bloodstream infections, most of the isolates produced a ctx-m enzyme, with ctx-m-15 being the most predominant enzyme [danmap 2009, danmap 2011, danmap 2014, hansen et al. microb. drug res. 2014]. only a minor part of the isolates carried plasmid mediated ampc (cmy variants). as observed in danmap 2014 and in hansen et al. the worldwide disseminated ctx-m-15 st131 was strongly represented in this study, but the danish e. coli isolates also belonged to other international sts (e.g., st38, st405, st410, st69 and st648) related to spread of esbls. the finding of three e. coli isolates with oxa-48 group enzymes (oxa-48 and oxa-181) from blood- stream infection is of concern. louise roer, frank hansen, anette m. hammerum and henrik hasman for further information: henrik hasman (henh@ssi.dk) table 1. distribution of esbl and carbapenemase producing e. coli from bloodstream infections, denmark 2015 2014 2015 region numbers numbers the capital region of denmark 110 116 the zealand region 27 14 region of southern denmark 43 45 central denmark region 43 59 north denmark region 22 41 total numbers 245 275 2014 2015 enzyme number % number % ctx-m-1 10 4% 7 3% ctx-m-14 1 38 16% 33 12% ctx-m-14 b 5 2% 5 2% ctx-m-15 1 121 49% 139 51% ctx-m-24 1 1 < 1% 5 2% ctx-m-27 1 25 10% 33 12% ctx-m-55 1 8 3% 14 5% ctx-m-10 1 12 5% 15 5% cmy-21 10 4% 6 2% other cmy variants 1 4 2% 10 4% other esbl enzymes 17 7% 15 5% oxa-48-group 1 3 1% 3 1% 2014 2015 mlst numbers % numbers % st131 124 51% 135 49% st38 18 7% 23 8% st405 13 5% 12 4% st410 4 2% 11 4% st69 10 4% 10 4% st648 7 3% 10 4% st12 5 2% 9 3% st10 0 0% 6 2% st1193 2 1% 5 2% other sts 1 62 25% 54 20% table 2. esbl enzymes and carbapenemases detected in e. coli from bloodstream infections 1 in some isolates more than one enzyme was detected in 2015 table 3. distribution of mlsts in e. coli from bloodstream infections 1 less than 5 isolates per st in 2015 danmap 2015 danmap 2015 danmap 2015
isolates-patients-cpe-114.html
