inhabitants-2015-consumption-51.html
DANMAP 2015 3D
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danmap 2015 52 antimicrobial
consumption
in humans 5. also the highest number of prescriptions redeemed per 1,000 inhabitants, while the central denmark region had the lowest, 574.4 and 494.5 prescriptions per 1,000 inhabitants, respec- tively. interestingly region zealand has the highest amount and proportion of phenoxymethylpenicillin consumed in the country (data not shown). thus the regional differences in
consumption
may resemble differences in local recommenda- tions and treatment guidelines as well as in custome. 5.3.4.
penicillins
penicillins
account for 2/3 of all antimicrobial
consumption
in primary health care, but while this has remained unchanged since 2006 individual changes in the
consumption
of the dif- ferent groups of penicillin have been observed. the consump- tion of
penicillins
in total increased slightly in 2015 (10.74
did
) compared to 2014 (10.58
did
). increases have been no- ticed for all years in the last decade except for the year 2013 to 2014, where no apparent increase was observed. from 2006 to 2015 the
consumption
of
penicillins
increased by 13% (corresponding to a total of 9.51
did
in 2006), (table 5.1). 20 year trends of the
consumption
of leading
penicillins
are shown in figure 5.6. the
consumption
of beta-lactamase sensi- tive
penicillins
was almost unchanged from 2014 to 2015, with a slight decrease of 1%. small increases in consump- tion were observed for beta-lactamase resistant
penicillins
(1.5%) and
penicillins
with extended spectrum (2.2%). marked increases were seen for ?combination
penicillins
? (9.2%). the
consumption
of these three groups has risen considerably over the past decade, with particular increases for beta-lactamase resistant
penicillins
from 1.05
did
to 1.38
did
(31%), penicil- lins with extended spectrum from 2.95
did
to 3.61
did
(22%) and the combination
penicillins
with betalactamase inhibitors from 0.12
did
to 1.42
did
(1183%). for the 20-year period beta-lactamase sensitive
penicillins
decreased with 3.8%,
penicillins
with extended spectrum increased with 44% and beta-lactamase resistant
penicillins
increased with 360%. the increases in percent for the combination
penicillins
cannot be estimated for the 20-year period since the
consumption
in 1996 was registered as being zero.
consumption
at the substance-level for the different peni- cillin groups is shown in figure 5.6. as mentioned above phenoxymethylpenicillin is the most consumed penicillin. in a 20-year chart trends in the
consumption
become very clear, for phenoxymethylpenicillin showing increasing trends for the first eleven years (from 4.50
did
in 1996 to 5.67
did
in 2007) and an almost equivalent but steeper decrease onwards to 2015 (4.33
did
). for all other
penicillins
the trends over the 20-year period were more stable, pivmecillinam and amoxicil- lin with clavylanic acid showing parallel increasing trends, pivmecillinam from the first registration in 2000, amoxicillin with clavulanic acid from 2005 and onwards. also flucloxacil- lin showed increasing trends paralleling the others from 2010 until 2014; this drug was introduced to the danish market in 2011 following delivery problems and production cessation of the oral mixture for dicloxacillin. in 2015 a reduction in
consumption
was observed. both pivmecillinam, pivampicillin and amoxicillin belong to the
penicillins
with extended spectrum; amoxicillin and pivampicil- lin slowly declined over the last twenty years, while pivmecil- linam increased steeply. the increase of pivmecillinam is due to changes in the recommended treatment of urinary tract infections (uti), where sulfamethizole used to be the prime drug, see figure 5.7 - 5.9 for the treatment of uti in women, 1999-2015. table 5.4.
consumption
of antimicrobial agents for systemic use in primary health care at regional level, denmark region indicator year 2011 2012 2013 2014 2015 capital region ddd/1000 inhabitants/day 17.9 16.9 16.9 16.3 16.4 prescriptions/1000 inhabitants 657.6 599.2 576.7 549.4 533.6 region zealand ddd/1000 inhabitants/day 17.8 16.7 16.9 16.5 16.9 prescriptions/1000 inhabitants 677.4 618.6 601.4 579.5 575.4 region of southern denmark ddd/1000 inhabitants/day 17.3 16.2 16.5 15.8 15.8 prescriptions/1000 inhabitants 658.0 598.4 588.9 556.5 540.3 central denmark region ddd/1000 inhabitants/day 16.0 15.3 15.5 15.1 15.2 prescriptions/1000 inhabitants 573.8 531.9 512.8 500.5 494.5 north denmark region ddd/1000 inhabitants/day 16.4 15.2 15.4 15.1 15.2 prescriptions/1000 inhabitants 620.1 557.6 541.2 525.6 510.6 denmark (total) ddd/1000 inhabitants/day 17.3 16.8 17.0 16.4 16.2 prescriptions/1000 inhabitants 637.4 581.1 564.2 542.2 530.9 danmap 2015
pivmecillinam-2015-prescriptions-53.html
