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DANMAP 2015 3D
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danmap 2015 50 antimicrobial consumption in humans 5. for tetracyclines, both the
number
of ddds per patient and ddds per package have continuously been higher than for any other antimicrobial group, primarily due to the fact that tet- racyclines are commonly used for acne treatment with higher dosages given in treatments of typically three, but up to six months. figure 5.4 shows the trends in consumption for the
number
of packages per 1,
000
inhabitants
per year compared to the treated patients per 1,
000
inhabitants
per year and the total consumption of ddds per 1,
000
inhabitants
per day for the last decade, when measured against the consumption 15 years ago. although the trends parallel each other, ddds per 1
000
inhabitants
per day remained above 110% through all ten years shown, compared to the index year 2001. from 2006 until 2011 increasing trends were observed with a peak of 123% in 2011, followed by gradual decreases. de- velopment in the
number
of treated patients and the
number
of packages show almost equal lines, starting at 102% and 100%, respectively, fluctuating around 100% in the period from 2006 to 2011 and, following distinct decreases, ending at 89% and 92%, respectively. when comparing the consumption of ddd per 1,
000
inhab- itants to the
number
of prescriptions and users per 1,
000
inhabitants
once more changes in the consumption of ddds are noted: the
number
of ddds increased from 2006 to 2011 (5,585 to 6,388 ddd/1,
000
inhabitants
) and slowly declined thereafter, reaching 5,913 ddd/1,
000
inhabitants
in 2015. the
number
of users and prescriptions paralleled each other in trends without noteworthy changes in the first six years, but with minor declines through the past four years. overall there was a decrease through the decade from 313 to 274 users/1,
000
inhabitants
and 587 to 511 prescriptions/1,
000
inhabitants
, respectively (figure 5.5). table 5.3 shows the
number
of prescriptions per 1,
000
inhabit- ants for leading antimicrobial agents in primary health care from 2006 to 2015. in 2015 530.62 prescriptions per 1,
000
inhabitants
were redeemed at pharmacies, a decrease of 12% from the 603.60 receptions per 1,
000
inhabitants
in 2006. generally, the
number
of prescriptions decreased by 24% from 2006 to 2015 (171.29 to 130.07 prescriptions per 1,
000
inhabitants
), compared to the 19% decrease in did shown in figure 5.2. for betalactam sensitive penicillins and combination penicillins fluctuations in the
number
of prescriptions followed fluctuations in dids. however, it is generally clear that changes in consumption measured as dids do not necessarily mirror changes in the
number
of prescriptions. for the penicillins with extended spectrum the
number
of prescriptions increased from 2006 until 2010, from 75.78 to 85.04 prescriptions per 1,
000
inhabitants
, but declined again to 74.88 prescriptions per 1,
000
inhabitants
in 2015. during the same time, the consumption measured in did gradually increased, from 2.95 did in 2006 to 3.61 did in 2015. for the beta-lactamase resistant penicillins the
number
of prescriptions increased from 2006 to 2011, (29.38 -30.34 pre- scriptions per 1,
000
inhabitants
) but decreased the next four years to 28.85 prescriptions per 1,
000
inhabitants
in 2015. this change in trends was not reflected in the consumption of did, that seemed almost unchanged but with a slight increase over the decade, from 1.05 did in 2006 to 1.38 did in 2015. 0 100 200 300 400 500 600 700 5
000
5200 5400 5600 5800 6
000
6200 6400 6600 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 prescriptions/users/1
000
inhabitants
ddd/1
000
inhabitants
ddd/1
000
inhabitants
prescriptions/1
000
inhabitants
users/1
000
inhabitants
fig 5.5 80% 90% 100% 110% 120% 130% 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 index: 2001 = 100% ddd/1
000
inh./day packages/1
000
inh./year treated pat./1
000
inh./year fig 5.4 figure 5.4. indicators of antimicrobial consumption (j01) in primary health care, denmark danmap 2015
inhabitants-2015-consumption-51.html
