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66 antimicrobial consumption in humans 5. sensitive penicillin increased in 2015 (89 % increase compared to 2014 and 119 % compared to 2013), as well as penicillin- ase-stable penicillin (14 % increase compared to 2014 and 77 % compared to 2013). see details in figure 1 and 2. another striking observation, both in hospital and primary
healthcare
, is the increase in the use of amoxicillin with enzyme inhibitor (ei), shown in figure 3. the cause of this increase remains to be elucidated. antimicrobial consumption in primary healthcare. total antimicrobial consumption in 2015 was 14.57 ddd/1,000 inhabit- ants/day (did) which represented an increase compared to 2014 (13.92 did) but was similar to earlier years. narrow-spectrum antimicrobials made up 55 % of the use in 2015; penicillinase-sensitive penicillin constituted 35 % of total did. the share of broad-spectrum antimicrobials was 14 %, among these the use of tetracyclins has decreased since 2013 but still constitutes 10 % of the total did. a further development in the use of pivmecillinam and ciprofloxacin is anticipated. see details in fig. 2 and 4. conclusion. antimicrobial consumption is still increasing, at ls as well as in primary healthcare. annual antibiotic audits have been in place since 2011. implementation of antibiotic stewardship and increased focus on adherence to general infection control precautions are the next steps in the effort to reduce development and spreading of antimicrobial resistance in ls and in primary healthcare. elsebeth tvenstrup jensen, anne kjerulf, william smith, hjørdis reinert, shahin gaini, kjartan mohr, ann winther jensen, niels joensen. for further information: etj@ssi.dk 5,04 ; 35% 1,18 ; 8% 0,38 ; 2% 1,34 ; 9% 0,76 ; 5% 0,13 ; 1% 0,41 ; 3% 1,43 ; 10% 1,43 ; 10% 2,47 ; 17% figur. 4. consumption of antimicrobials in primary healthcare, 2015 (ddd/1,000 patients/day; %) penicillin penicillinase-stable penicllins pivmecillinam ampicillins amoxicillin with ei cephalosporins ciprofloxacin tetracyclins macrolides others continued ... textbox 5.2 figure. 4. consumption of antimicrobials in primary healthcare, 2015 (ddd/1,000 patients/day; %) danmap 2015
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